<!DOCTYPE html>
<html lang="en">
<head>
    <meta charset="UTF-8">
    <title>Title</title>
    <style>
        .box {
            width: 200px;
            height: 200px;
            border: 1px solid #ccc;
            display: flex;
            flex-wrap: wrap;
            align-content: space-between;
        }

        .column {
            flex-basis: 100%;
            display: flex;
            justify-content: space-between;
        }
    </style>
</head>
<body>
<div class="box">
    <div class="column">
        <span class="item">1</span>
        <span class="item">2</span>
    </div>
    <div class="column">
        <span class="item">3</span>
        <span class="item">4</span>
    </div>
</div>
</body>
</html>